THYMIC REGENERATION — AGE-REGRESSION.COM

THYIC REGENERATION

Thymic Involution

⫸ It is clear that a major event contributing to age-associated immune system changes is the physiological process of thymic involution (Fig. 2.4, below this page). After puberty, a progressive reduction in the size of the thymus size takes place, areas of active thymopoiesis decrease and the organ shrinks (Aspinall et al. 2010). This evolutionarily programmed process is supported by increased levels thymo-suppressive cytokines, such as leukaemia inhibitory factor, oncostatin M, and IL-6 (Sempowski et al. 2000), with a simultaneous decrease of IL-7 secretion. These alterations negatively affect the numbers of thymic epithelial cells and lead to decreases in thymopoiesis. The contraction of thymic output and consequently reduced capacity to replace the circulating naïve T lymphocytes after their activation and differentiation is believed to be an important element contributing to the development of immunosenescence (Aspinall et al. 2010; Müller and Pawelec 2014). ⫷ [A4]

(Thymic Wikilink) - (Last Revision: 3/26/2022)

◉ The thymus is the main site of T cell maturation and development.

◉ The thymus is the first organ to develop in a fetus.

◉ Thymus involution is directly related to the age-related immune system decline

◉ Regenerating the thymus has broad immunological and age regressive benefits.

◉ Human Growth Hormone is able to regenerate the human thymus.

◉ Thymic regeneration has broad immunological and age related benefits

◉ Thymic regeneration reduces your risk to all age-related diseases.

◉ Thymus Regeneration lowers your BASP.

The Thymus is an organ critical to the development of you immune system. As you age it atrophies or shrinks and looses its ability to provide the microenvironment required to mature Thymic derived lymphocytes, more commonly referred to as T-Cells. Central to this degenerative process is the replacement of epithelial cells with fat cells. These T-cell maturation processes are critical in developing adaptive immunity. It is also generates the first defense against autoimmune responses as the thymic environment trains T-cells to differentiate between cellular proteins (self) and foreign antigens (non-self). You can click on the images below to enlarge them. Small human studies have demonstrated that regenerating thymus has broad age regressive benefits and lowers you BASP.

Gregory Fahy, Ph.D., is a leader advancing the field of thymic regeneration in humans as a disease preventive and age regression intervention.

“Using a protocol intended to regenerate the thymus, we observed protective immunological changes, improved risk indices for many age-related diseases, and a mean epigenetic age approximately 1.5 years less than baseline after one year of study and 2.5 years at the conclusion of the study.” If this does not sound dramatic, consider that having the ability to regress you BASP by one year, every year, would mean that you would never die. Dr. Fahy refers to this as “escape velocity.” No one is making that claim, but it underscores that a 2.5 year reduction in your BASP is dramatic. [A1]

Dr Fahy through a private commercial company is currentely conducting a clinical trail of HGH, Metformin and DHEA. You can find additional information and a form to get screened for that study here: Intervene Immune

Thymic Involution and Resulting Hematopoiesis Dysregulation

THYMIC REGENERATION by Various Modalities

[6] [2020] Mechanism for the Increase in Human Growth Hormone with Administration of Amino Acids and Supplements

► GH has been shown to modulate various functions of the thymus. We now demonstrate the production of human GH (hGH) by human thymic cells, and the expression of GH receptors in thymic epithelial cells (TEC) and in thymocytes at different stages of differentiation.

Hormones and neuropeptides can be potent immunomodulators that participate in various functions of the immune system (1, 2). One of the targets for neuroendocrine control is the thymus gland, a primary lymphoid organ in which bone marrow-derived T cell precursors undergo a complex process of maturation, which involves sequential expression of various membrane proteins and rearrangements in T cell receptor genes (3, 4). ◀︎[A3]

It is possible to increase the systemic levels of HGH by a variety of supplements and therapeutics. Gregory Fahy and others have demonstrated that increasing HGH can re-constitute the atrophied thymus resulting in immunological and age regression benefits. A combination of amino acids and supplements have also demonstrated the ability to increase the systemic levels of HGH. Somatostatin is a Growth Hormone Releasing Hormone (GHRH) that directly signals cells to produce HGH.

If you intend to pursue this approach I would encourage you to first apply for Dr. Fahy’s clinical research protocol. HGH Clinical Trial

A combination of amino acids and supplements has demonstrated the ability to increase levels of HGH. The mechanism of action has been identified as inhibiting Somatostatin, also known as growth hormone-inhibiting hormone (GHIH). By blocking the natural inhibitor of the production of HGH you release the negative regulation inhibiting its production. This provides those perusing thymic regeneration with an alternative to obtaining and injecting HGH. The identified list of amino acids and supplements is available in a commercial product called SeroVital. Each component identified in the published research is available individually online. [B1-B6]

Calorie Restriction ▲ HGH

Calorie restriction has also demonstrated improvements in the thymic microenvironment. Researchers found that reducing caloric intake by 14%, for two years, with no dietary restrictions other than total calories, seemed to increase the functional volume of the thymus gland compared to data gathered at the beginning of the trial. MRI was also utilized in this study to make this determination. A reduction in fat around the gland was also detected, compared to little change in the control group with no dietary restriction. [C1]

Low Dose Melatonin ▲ Oxytocin, Vasopressin and HGH

After the administration of melatonin in doses of 0.05, 0.5 or 5.0 mg or placebo, It was demonstrated that melatonin produced dose-dependent changes in circulating concentrations of oxytocin and vasopressin, the 0.5 mg dose being stimulatory, while 5.0 mg was inhibitory. These two doses stimulated growth hormone release, while there was no significant effect on prolactin or cortisol release. CONCLUSIONS These results confirm that the nocturnal increase in melatonin could contribute to the patterns of oxytocin, vasopressin and growth hormone release seen over 24 h.

Melatonin in physiological concentrations stimulates the release of growth hormone and the neurohypohisysial hormones, oxytocin and vasopressin, an effect that may contribute to the nocturnal rise of these hormones. By contrastthere was little effect on corticol and prolactin. In higher doses melatonin inhibited neurohypophysial hormone release, while still stimulating growth hormone release. [D1]

Other studies show a less robust response, but all incorporated higher doses of melatonin.

Thymalin: Studies have shown that this immunomodulator molecule does occur naturally in the thymus. The thymus is a specialized lymphoid organ. It is critical to the development of active T-cells as part of a functioning immune system.

The decreased or missing activity of the thymus in old age is associated with increased susceptibility to severe infections and cancer development. It impairs the immune response to infections and the immune surveillance against tumors.
Thymic immunomodulators seem to have the potential of restoring the integrity of thymic activity in the thymus. In this way immune responses to infections and are up-regulated.

Researchers of the St. Petersburg Institute of Bioregulation and Gerontology of the North-Western Branch of the Russian Academy of Medical Sciences and the Institute of Gerontology of the Ukrainian Academy of Medical Sciences (Kiev) clinically assessed the geroprotective effects of thymic (Thymalin) and pineal Epithalamin (Epitalon) peptide bioregulators in 266 elderly and older persons during 6–8 years both peptides were given at 10 mg daily for ten consecutive days once every 6 months.

“The obtained results convincingly showed the ability of the bioregulators to normalize the basic functions of the human organism, i.e. to improve the indices of cardiovascular, endocrine, immune and nervous systems, homeostasis and metabolism. Homeostasis restoration was accompanied by a 2.0–2.4-fold decrease in acute respiratory disease incidence, reduced incidence of the clinical manifestations of ischemic heart disease, hypertension disease and osteoporosis as compared to the control.
Such a significant improvement in the health state of the peptide-treated patients correlated with decreased mortality rate during observation: 2.0–2.1-fold in the Thymalin-treated group; 1.6–1.8-fold in the Epithalamin-treated group; 2.5-fold in the patients treated with Thymalin plus Epithalamin (Epitalon) as compared to the control.”
A separate group of patients was treated with Thymalin in combination with Epithalamin annually for 6 years and their mortality rate decreased 4.1 times as compared to the control.

(An additional overview of thymus peptide studies and actions can be found here.)

Format for Dosage, Change all Below

AIR AGENT / TIME

Human Growth Hormone as injected therapeutic - or

Human Growth Hormone as induced by amino acids and supplements:

l-lysine HCl,

l-arginine HCl,

oxo-proline,

N-acetyl-l-cysteine,

l-glutamine,

Schizonepeta (aerial parts) powder

The combination of supplements itemized above is available as a commercial product called: SeroVital.

Somatostatin: Growth Hormone Releasing Hormone (GHRH)

Melatonin ▲ HGH

Reduced Sugar Intake ▲ HGH

Zinc ▲ HGH

Hi-Quality Sleep ▲ HGH

TIME

DOSAGE / ROUTE

Dose response guided by Insulin levels post administration of HGH

1000 mg, Oral

Administered as a spray directly into the nasal cavity.

0.5 mg

NOTES

ROUTE

INTERVAL

With Food

Concomitant / Synergistic / Additive / Protective

Metformin and DHEA

Metformin and DHEA are administered to modulate the increase of Insulin like growth factor 1 (IGF-1) that accompanies the increase of HGH. This is an active intervention blocking the GH-induced hyperinsulinemia and possible development a signaling environment that might exacerbate cancerous or precancerous foci in the prostate.

NOTES

🔷 ? 🔷

🔷 ? 🔷

🔷 ? 🔷

🔷 ? 🔷

🔷 ? 🔷

TED talk by Greg Fahy on Thymic Regeneration and Age Regression.

A more in depth and detailed presentation by Dr Fahy can be found here:

Lifespan: Greg Fahy | Thymus Regeneration

► Thymic involution is central to the decline in immune system function that occurs with age. By regenerating the thymus, it may therefore be possible to improve the ability of the aged immune system to respond to novel antigens. ◀︎[A2]

(A) THYMIC REGENERATION - HGH -

[A1] [2019] Reversal of epigenetic aging and immunosenescent trends in humans

[A2] [2014] Regeneration of the aged thymus by a single transcription factor

[A3] [1998] Growth Hormone and Its Receptor Are Expressed in Human Thymic Cells

[A4] [2018] Biochemistry and Cell Biology of Ageing- Part II Clinical Science

(B) AMINO ACIDS, SUPPLEMENTATION -

[B1] [2006] Plasticity of neuroendocrine–thymus interactions during ontogeny and ageing: Role of zinc and arginine

[B2] [2020] Mechanism for the Increase in Human Growth Hormone with Administrationof a Novel Test Supplement and Results Indicating ImprovedPhysical Fitness and Sleep Efficiency

[B3] [2018] Clinical Trial Results: Effects of an Amino Acid-Based hGH Secretagogue on Triiodythyronine

[B4] [2019] Increased Human Growth Hormone After Oral Consumption of an Amino Acid Supplement: Results of a Randomized, Placebo-Controlled, Double-Blind, Crossover Study in Healthy Subjects

[B5] [2020] Increased human growth hormone following oral consumption of an amino acid supplement: results of a randomized, placebo- controlled, double-blind, crossover study in healthy subjects